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dc.contributor.authorAlhazmi, Hadeel
dc.date.accessioned2021-04-26T19:46:59Z
dc.date.available2021-04-26T19:46:59Z
dc.date.issued2021-04-20
dc.identifier.citationAlhazmi, Hadeel. Antimicrobial and Chemical Studies on a Medicinally important Plant: Curcuma longa; A thesis submitted to the Faculty of Graduate Studies of The University of Winnipeg [in partial fulfillment of the requirement of the degree] Master of Bioscience Technology and Public Policy, Department of Biology. Winnipeg, Manitoba, Canada: The University of Winnipeg, 2021. DOI: 10.36939/ir.202104261444.en_US
dc.identifier.urihttps://hdl.handle.net/10680/1927
dc.description.abstractThis thesis describes phytochemical studies on the methanolic extract of Curcuma longa; a medicinally important plant used as indigenous medicine for the treatment of wounds in South Asian and African countries. The crude extract displayed antibacterial activity against the Gram-positive bacterium, Staphylococcus aureus, but was inactive against Gram-positive bacterium Streptococcus agalactiae. This extract also did not show antibacterial activity against Gram-negative bacteria, Escherichia coli and Pseudomonas aeruginosa. Based on the observed antibacterial activity, it was decided to carry out phytochemical investigation of crude methanolic extract of C. longa to isolate and characterize natural products and evaluate them for antimicrobial activity. These efforts resulted in the identification of three known natural products: curcumin (39) sclareolide (40) and atalantoflavone (41). Structures of these compounds were established with the aid of NMR spectroscopic studies. Compounds (40) and (41) have been isolated for the first time from this plant. Compounds (39-41) were found to be inactive against the Gram-positive bacterium, Staphylococcus aureus, and Gram-negative bacterium, Escherichia coli.en_US
dc.language.isoenen_US
dc.publisherUniversity of Winnipegen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCurcuma longaen_US
dc.titleAntimicrobial and Chemical Studies on a Medicinally important Plant: Curcuma longaen_US
dc.typeThesisen_US
dc.description.degreeMaster of Bioscience Technology and Public Policy, Department of Biologyen_US
dc.publisher.grantorUniversity of Winnipegen_US
dc.identifier.doihttps://doi.org/10.36939/ir.202104261444en_US


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